Advances in the regulatory roles of exosomes on pathological process of schistosomiasis hepatic fibrosis
10.16250/j.32.1374.2018009
- VernacularTitle:外泌体对血吸虫病肝纤维化病理进程的调节作用研究进展
- Author:
Yong-hua ZHOU
1
;
Xian-shi TANG
1
;
Li-juan SHEN
2
;
Xuan DONG
1
;
Ke WANG
2
;
Jun-Qi YANG
1
;
Yong-liang XU
1
Author Information
1. Key Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China
2. Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine, China
- Publication Type:Journal Article
- Keywords:
Schistosomiasis;
Exosome;
Hepatic fibrosis;
Regulatory role
- From:
Chinese Journal of Schistosomiasis Control
2018;30(5):596-600
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are a group of membraneous vesicles generated and released by multi-vesicular bodies or cell membranes in a variety of cell types. Acting as important messages between cells, they participate in almost every physiological and pathological process of living organisms. Exosomes contain specific proteins, mRNA, miRNAs, etc. and mediate intercellular communications, signal transductions and gene expressions effectively. Exosomes are involved in the formation of hepatic fibrosis, which is the typical liver pathological change in the progression of schistosomiasis and is caused by the liver repair and (or) regeneration involving inflammation stimulated by exosomes, activated hepatic stellate cells and other related pathways in reaction to the parasite infection. Exosomes could serve as new markers for schistosomiasis hepatic fibrosis diagnosis and potential targets for its treatment. This paper briefly reviews the latest development of studies on the regulatory roles of exosomes in schistosomiasis hepatic fibrosis, so as to provide ideas for searching new treatment targets of the disease.
