Treg/Th17 balance and immunology of schistosome infection: a review
10.16250/j.32.1374.2018001
- VernacularTitle:Treg/Th17平衡与血吸虫感染免疫
- Author:
Yan-ru GAO
1
;
Wei-wen CHEN
2
;
Jia-wang LI
2
;
Hui-lan ZOU
3
Author Information
1. Medical Department, City College, Wuhan University of Science and Technology, Wuhan 430083, China
2. School of Medicine, Wuhan University of Science and Technology, China
3. Wuchang Hospital Affiliated to Wuhan University of Science and Technology, China
- Publication Type:Journal Article
- Keywords:
Schistosome;
Treg/Th17 balance;
Immunopathology;
Immune regulation
- From:
Chinese Journal of Schistosomiasis Control
2018;30(5):588-591
- CountryChina
- Language:Chinese
-
Abstract:
Many factors are reported to be involved in regulating the immunopathogenesis of schistosome infection. CD4+ T cell is one of the key players in the regulation of the liver granuloma formation by differentiation into different effector subsets including T helper (Th) 1, Th2, Th17, and T regulatory cells (Treg cells). Treg cells play an important suppressive role in immunopathology control and favor the pathogen to escape from the host immune assault. The functional activity of Tregs has been related to some autoimmune diseases including asthma and inflammatory bowel disease, which suggests that the manipulation of Tregs to restore their numbers and function may be therapeutic. However, interleukin-17 (IL-17) is a pro-inflammatory cytokine involved in the pathogenesis of many inflammatory and infectious conditions, including schistosomiasis. Therefore, a deeper understanding of the mechanisms of these immune regulations is necessary for the better control of pathology in schistosomiasis. In this paper, we review the Treg/Th17 balance and the immunology of schistosome infection.
