Association between neuroimmunological indicators and autism spectrum disorders
10.16835/j.cnki.1000-9817.2019.04.007
- VernacularTitle:神经免疫指标与孤独症谱系障碍的关联
- Author:
WANG Lin, YANG Xiaolei, MA Yongjuan, LIU Xiaocui, ZOU Mingyang, SUN Caihong, WU Lijie
1
Author Information
1. Department of Child and Adolescent Health, Public Health College, Harbin Medical University, Harbin(150081), China
- Publication Type:Journal Article
- Keywords:
Osteopontin;
Interleukin-17;
Autistic disorder;
Case-control studies;
Child
- From:
Chinese Journal of School Health
2019;40(4):499-502
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship among osteopontin(OPN), Interleukin-17A(IL-17A), anti-MBP auto-antibody and autism spectrum disorder(ASD), and to provide the theoretical basis for the etiology and pathogenesis of ASD.
Methods:Forty autistic children and forty matched healthy children were enrolled in this case-control study. The levels of OPN, IL-17A, anti-MBP autoantibody in serum were measured by enzyme-linked immunosorbent assay (ELISA). The associations between those metabolic levels and the severity and intelligence of ASD children were performed by Pearson or Spearman correlation.
Results:Children with ASD had higher serum levels of OPN, IL-17A [(296.89±162.95),0.93] pg/mL compared to healthy control[(217.98±113.39), 0.62] pg/mL(P<0.05). Serum OPN, IL-17A, and anti-MBP auto-antibody levels in ASD group were not correlated with the scores of ABC, CARS, and PPVT(P>0.05). However, anti-MBP auto-antibodies level in children with ASD were positively correlated with OPN and IL-17A levels, respectively(r=0.35, 0.34, P<0.05).
Conclusion:It was obvious that the ASD children were found with neuroimmunologic abnormality, and the underlying mechanism needs to be further explored.
