The Examination of PUVA-Induced Dermatologic and Ophthalmologic Manifestations in Systemic PUVA Therapy.
- Author:
Jee Ook KIM
1
;
Ki San KIM
;
Kyu Suk LEE
Author Information
1. Department of Dermatology, College of Medicine, Keimyung University, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
PUVA;
Dermatologic and ophthalmologic manifestations
- MeSH:
Burns;
Female;
Follow-Up Studies;
Humans;
Hyperpigmentation;
Lentigo;
Male;
Pruritus;
Psoriasis;
PUVA Therapy*;
Vitiligo
- From:Korean Journal of Dermatology
2001;39(7):749-754
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Systemic PUVA therapy is a widely used method for treatment of vitiligo and psoriasis. However, there have been few studies concerning complications of systemic PUVA therapy. OBJECTIVE: We examined the dermatologic and ophthalmologic manifestations in patients receiving PUVA therapy. METHOD: We studied 42 patients who received systemic PUVA therapy for more than six months in our department. RESULTS: The results are summarized as follows. 1. Among the 42 patients, the number of male and female patients were 18(42.9%) and 24(57.1%) respectively. The mean age at the start of PUVA was 42 years and mean cumulative UVA dase was 996 J/cm2. 2. Among the 42 patients, hyperpigmentation found in 9(21.4%), PUVA lentigo in 8(19.0%), pruritus in 5(11.9%) and burn in 3(7.1%). 3. The ophthalmologic manifestations were conjunctivitis(13 cases, 31.0%), pteygium(7 cases, 16.7%), pingueculum(6 cases, 14.3%) and cataract(3 cases, 7.1%). CONCLUSION: Long term exposure to PUVA causes chronic clinical side effects of PUVA. Therefore careful follow-up of patients who receive long term PUVA therapy is necessary.
