Relationship between clustering of metabolic disorders and left ventricular hypertrophy in hypertensive children and adolescents
10.16835/j.cnki.1000-9817.2019.06.006
- VernacularTitle:高血压儿童青少年代谢异常指标聚集性与左心室肥厚的关系
- Author:
SHUI Wang, YANG Lili, XI Bo
1
Author Information
1. Department of Epidemiology, School of Public Health, Shandong University, Jinan (250012), China
- Publication Type:Journal Article
- Keywords:
Hypertension;
Metabolic diseases;
Hypertrophy,left ventricular;
Child;
Adolescent
- From:
Chinese Journal of School Health
2019;40(6):812-814
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the relationship between clustering of metabolic disorders and left ventricular hypertrophy (LVH) in hypertensive children and adolescents, and to provide the reference for preventing the damage to their heart structure.
Methods:Based on the data from the Twelfth Five-year National Science and Technology Support Program “Early Warning, Diagnosis and Treatment of Cardiovascular Disease in Children” from September 2012 to September 2014 in Jinan, 261 children and adolescents aged 6-17 years whose hypertensive status was confirmed based on appearance of elevated blood pressure across three different occasions were included. Covariance analysis was used to analyze the relationship of clustering of metabolic disorders with left ventricular mass index levels. Multivariable logistic regression model was used to examine the relationship of clustering of metabolic disorders with LVH.
Results:After adjustment for sex, age and blood pressure, LVMI levels were (33.21±1.85) (38.57±1.19) and (43.00±1.63)g/m2.7, respectively, for hypertensive children and adolescents carrying 0, 1 and ≥2 metabolic disorders; LVMI levels increased with the number of metabolic disorders in hypertensive children and adolescents (P<0.01). Compared with the hypertensive children and adolescents without any metabolic disorders, the risk for LVH increased in ones carrying 1 and ≥2 metabolic disorders, the odds ratios and 95% confidence intervals were 2.41(1.11-5.23) and 4.69(2.05-10.74), respectively.
Conclusion:The clustering of metabolic disorders was positively correlated with the LVMI levels and risk of LVH in hypertensive children and adolescents. Therefore, to prevent cardiac damage such as LVH in hypertensive children and adolescents, it is important to prevent and control metabolic disorders comprehensively.
