Diagnosis of perinuclear anti-neutrophil cytoplasmic antibody-associated microscopic polyangiitis in silicotics: case report.
10.1186/s40557-016-0108-1
- Author:
Ji Won LEE
1
;
Jun Pyo MYONG
;
Yeong Jin CHOI
;
Seyoung LEE
;
Bum Seak JO
;
Jung Wan KOO
Author Information
1. Department of Occupational and Environmental Medicine Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-Daero Seocho-gu, Seoul, 137-701 Republic of Korea. dr_mjp@naver.com
- Publication Type:Case Report
- Keywords:
Occupational exposure;
Silicon dioxide;
Silicosis;
Autoimmune disease
- MeSH:
Acute Kidney Injury;
Ambulatory Care Facilities;
Arthritis, Rheumatoid;
Autoimmune Diseases;
Compensation and Redress;
Cytoplasm*;
Diagnosis*;
Diet;
Dust;
Dyspnea;
Early Diagnosis;
Glomerular Filtration Rate;
Headache;
Hematuria;
Hemoptysis;
Humans;
Lupus Erythematosus, Systemic;
Male;
Microscopic Polyangiitis*;
Middle Aged;
Occupational Exposure;
Pneumoconiosis;
Scleroderma, Systemic;
Silicon Dioxide;
Silicosis;
Smoke;
Smoking;
Vasculitis
- From:Annals of Occupational and Environmental Medicine
2016;28(1):21-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: An association between silica exposure and autoimmune diseases including rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, and anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis has been made. CASE PRESENTATION: A 56-year-old male presented with silicosis and had an occupational history of precious metal processing for 30 years and a 30 pack-year smoking history. The patient was diagnosed with pneumoconiosis and received compensation. No other complications were reported for pneumoconiosis. The patient suddenly presented with a non-specific headache for several days and microscopic hematuria was identified upon examination in the outpatient clinic. Following several weeks, the patient presented with aggravated dyspnea and hemoptysis, and his Modification of Diet in Renal Disease estimated glomerular filtration rate indicated acute kidney injury. Diagnostic analysis revealed perinuclear ANCA-associated microscopic polyangiitis (p-ANCA-associated MPA). CONCLUSION: Exposure to silica dust was likely one of the cause of p-ANCA-associated MPA. Possible pathogenic mechanisms of autoimmune diseases in silicotics and emphasis of the necessity for early diagnosis are discussed.
