Recent advances in clinical treatment and molecular mechanism of pulmonary fibrosis induced by paraquat poisoning
10.16571/j.cnki.1008-8199.2020.03.020
- VernacularTitle: 百草枯中毒致肺纤维化临床治疗及分子机制研究进展
- Author:
Ci-ru LI
1
;
Shi-nan NIE
1
Author Information
1. Department of Emergency Medicine,Jinling Hospital,Southern Medical University/General Hospital of Eastern Theater Command, PLA, Nanjing 210002, Jiangsu, China
- Publication Type:Journal Article
- Keywords:
paraquat;
poisoning;
pulmonary fibrosis;
clinical treatment;
molecular mechanism
- From:
Journal of Medical Postgraduates
2020;33(3):322-326
- CountryChina
- Language:Chinese
-
Abstract:
The main causes of death for paraquat poisoning are irreversible pulmonary fibrosis, respiratory failure and even multiple organ failure. Currently, the main clinical treatment methods are gastric lavage, catharsis, blood purification and symptomatic supportive treatment, but the effectiveness is not satisfactory. It has made some progress in clinical treatment of paraquat poisoning and the study of molecular mechanisms at home and abroad. The article simply reviews in the clinical treatment of pulmonary fibrosis induced by paraquat poisoning such as blood purification, antioxidants, glucocorticoid, Chinese medicine treatment, and the molecular mechanism research such as epithelial-mesenchymal transition, Wnt/β- catenin pathway, the NF-κB pathway and Akt-Nrf-2 pathways.
