The predictive value of preoperative fibrinogen level in peripheral blood combined with platelet-to-lymphocyte ratio in the prognosis of colorectal cancer
10.16571/j.cnki.1008-8199.2020.03.011
- VernacularTitle: 术前外周血纤维蛋白原水平联合血小板与淋巴细胞比值的评分对结直肠癌中预后的评估价值
- Author:
Jian-zhong DENG
1
;
Jian-hua JIN
1
;
Wen-bin LU
1
;
Qian LIU
1
;
Hua ZHANG
1
;
Li-yan JIN
1
;
Wen-jing LI
1
Author Information
1. Department of Onocology, Changzhou Wujin People′s Hospital, Changzhou 221003, Jiangsu, China
- Publication Type:Journal Article
- Keywords:
fibrinogen;
platelet-to-lymphocyte ratio;
F-PLR;
colorectal cancer;
prognosis
- From:
Journal of Medical Postgraduates
2020;33(3):274-279
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveThe local recurrence or distant metastasis of colorectal cancer (CRC) after surgical resection still directly affects the prognosis of CRC patients.This study aims to investigate the clinical significance of preoperative peripheral blood fibrinogen (Fbg) level combined with platelet-to-lymphocyte ratio (PLR) in the prognosis of CRC.MethodsThe clinicopathological characteristics of 108 CRC patients who were diagnosed by pathology and underwent surgical resection in Wujin hospital affiliated to Jiangsu University from January 2013 to December 2015 were analyzed. Fbg and PLR thresholds were determined by ROC curve, and the patients were grouped according to Fbg combined with PLR (F-PLR) to analyze the relationship between different F-PLR scores and the clinicopathological characteristics and prognosis of CRC patients.ResultsPLR showed statistically significant difference in the left and right half of the tumor (P<0.05), while Fbg and f-plr showed no significant difference in age, tumor site and lymph node metastasis (P>0.05). Multivariate analysis using COX regression showed that F-PLR score, TNM stage and lymph node metastasis were independent risk factors for the prognosis of CRC patients (P<0.05).ConclusionThe F-PLR score (Fbg and PLR combined) can be used as a predictor of treatment effect and prognosis of CRC patients to guide clinical treatment decisions and prognoses.
