Effect of glucose metabolism on hypothalamus-pituitary-thyroid axis

VernacularTitle: 葡萄糖代谢对下丘脑垂体甲状腺轴影响的研究进展
Author: Bo ZHANG ¹ ; Ya-qiu JIANG ¹
Author Information

1. Department of Endocrinology and Metabolism,Institute of Endocrinology, Liaoning Key Laboratory of Endocrine Diseases, The First Hospital,China Medical University,Shengyang 110001,Liaoning,China
Publication Type:Journal Article
Keywords: glucose metabolism; thyroid hormone; hypothalamus-pituitary-thyroid axis; molecular mechanism
From: Journal of Medical Postgraduates 2020;33(2):192-196
CountryChina
Language:Chinese
Abstract: Glucose is the basic metabolic substrate and main source of energy for the body. A complex neuroendocrine system regulate blood glucose concertration to keep it at a constant level. Thyroid hormones participate in the regulation of glucose metabolism through the PI3K/ERK and other signaling pathways. At the same time, abnormal glucose metabolism can cause the abnormal regulation of hypothalamus pituitary thyroid axis. In this paper, we review the change and molecular mechanism of thyroid hormone, thyroid stimulating hormone and thyroid releasing hormone in Hypoglycemia and Hyperglycemia.