The role of microRNA in chronic myeloid leukemia

VernacularTitle: 微小分子RNA与慢性髓性白血病关系的研究进展
Author: Shu-xian WANG ¹ ; Fang-fang WANG ¹ ; Duo-nan YU ¹
Author Information

1. Jiangsu Key Laboratory of Experiment & Translation Noncoding RNA Research, Yangzhou University School of Medicine, Yangzhou 225100, Jiangsu, China
Publication Type:Journal Article
Keywords: microRNA; chronic myeloid leukemia; tyrosine kinase inhibitor; cancer diagnostic biomarker; therapeutic target
From: Journal of Medical Postgraduates 2020;33(2):188-191
CountryChina
Language:Chinese
Abstract: Chronic myeloid leukemia（CML）is a common hematological malignancy. Although tyrosine kinase inhibitors（TKIs）have greatly improved the prognosis of CML patients，there are still several defects with TKI treatment including TKI resistance, toxic effects causing intolerance, etc. MicroRNA（miRNA） is a class of non-coding, single-stranded and small RNAs which encoded by endogenous genes and are about 19 to 24 nucleotides in length. miRNAs are closely related to the occurrence，development and prognosis of various tumors. In recent years，many studies have focused on the relationship betweenmiRNA and CML. In this paper，we review therelationship between miR-139-5p，miR-320a，miR-362-5p，miR-126， miR-199a/b-5p，miR-451 and CML .