Research progress of the relationship between endothelial progenitor cells and cardiovascular complications in diabetes
10.16571/j.cnki.1008-8199.2020.01.016
- VernacularTitle: 内皮祖细胞与糖尿病患者心血管并发症关系的研究进展
- Author:
Yu-hua LIU
1
;
Lu ZHAI
;
De-feng ZHAO
;
Xia DAI
Author Information
1. Department of Respiratory Medicine,2
- Publication Type:Journal Article
- Keywords:
diabetes;
endothelial progenitor cells;
cardiovascular
- From:
Journal of Medical Postgraduates
2020;33(1):88-92
- CountryChina
- Language:Chinese
-
Abstract:
70% to 80% of people with diabetes died from cardiovascular complications, which had become the leading cause of death in diabetic patients. Cardiovascular complications in diabetic patients are mainly associated with vascular endothelial dysfunction and poor neovascularization. Its important influencing factors are changes in the number of endothelial progenitor cells and dysfunction. Hyperglycemia in diabetic patients can cause endothelial progenitor cell dysfunction, inhibit its proliferation ability, angiogenesis ability and paracrine effect. In order to provide research ideas for the prevention and treatment of cardiovascular complications in diabetic patients, this article aims to review the relevant mechanism of the effect of hyperglycemia on the number and function of endothelial progenitor cells in patients with diabetes, and the application of endothelial progenitor cells in the treatment of diabetic cardiovascular disease.
