Progress research of the contribution over the interaction between intestinal flora and host miRNA to diabetes mellitus

VernacularTitle: 肠道菌群与宿主miRNA的相互调控作用及其与糖尿病相关性的研究进展
Author: Li-sha LI ¹ ; Qiong-Ying HU ² ; Da-qian XIONG ²
Author Information

1. Department of Medical Technology, Chengdu University of TCM, Chengdu 610072, Sichuan, China
2. Department of Laboratory Medicine, Affiliated Hospital of Chengdu University of TCM, Chengdu 610075, Sichuan, China
Publication Type:Journal Article
Keywords: gut microbiota; microRNAs; metabolic diseases; diabetes mellitus
From: Journal of Medical Postgraduates 2019;32(9):1004-1008
CountryChina
Language:Chinese
Abstract: Gut microbiota plays an important role in maintaining intestinal barrier function and keeping body health. Changes of its structure and function are related to many common human diseases. As a class of non-coding single-stranded molecules, numerous studies have shown that the regulatory effect of microRNAs (miRNAs) at the gene level, can affect almost all biological processes in the body. In addition, gut microbiota can interact with miRNAs, and play a regulatory role in maintaining intestinal homeostasis and preventing metabolic diseases(diabetes) together. In this paper, we review the regulation of gut microbiota-miRNAs interaction, and how to regulate the occurrence and development of diabetes mellitus through this interaction.