Research progress on serum magnesium disorder and its effects in patients with chronic kidney disease
10.16571/j.cnki.1008-8199.2019.09.016
- VernacularTitle: 慢性肾脏病患者血镁紊乱及影响的研究进展
- Author:
Shu-jun LIN
1
;
Tian-biao ZHOU
1
Author Information
1. Department of Nephrology, The Second Affiliated Hospital of Shantou University Medical College,Shantou 515041,Guangdong,China
- Publication Type:Journal Article
- Keywords:
magnesium disorder;
chronic kidney disease;
hypertension;
vascular calcification;
mineral metabolism;
mortality;
magnesium-based phosphorus binder
- From:
Journal of Medical Postgraduates
2019;32(9):978-983
- CountryChina
- Language:Chinese
-
Abstract:
The effect of blood magnesium disorder on chronic kidney disease (CKD) has been gradually confirmed in recent years. At present, magnesium homeostasis depends on dietary intake, gastrointestinal absorption and kidney metabolism. In recent years, it has been proposed that the magnesium concentration of dialysate and the influence of drugs (especially proton pump inhibitors) on magnesium homeostasis cannot be ignored in the treatment of CKD patients. Although the mechanism of the effect of magnesium on CKD has not been fully elucidated, recent studies suggest that magnesium deficiency may aggravate hypertension and vascular calcification in CKD patients, affecting mineral metabolism, leading to increased mortality. The application of different magnesium-based binders, such as magnesium citrate, calcium acetate/magnesium carbonate, and magnesium oxide, can help to alleviate the effect of low magnesium levels on CKD, which needs further research.
