Clinical study on the correlation of peripheral blood circulating tumor cells and theirchemokine receptor CCR9 with non-small cell lung cancer
10.16571/j.cnki.1008-8199.2019.09.010
- VernacularTitle: 外周血循环肿瘤细胞及其趋化因子受体CCR9与非小细胞肺癌的临床相关性
- Author:
Si-yang LIN
1
;
Yan-rong HAO
;
Yan-ru LÜ
;
Guo-sheng FENG
;
Hui LIN
;
Bai-jun LI
;
Xian-bin YUAN
;
Yu-hua CAO
;
En-cun HOU
;
Xiang LU
Author Information
1. Gradute School, Guangxi Medical University,Nanning 530021,Guangxi,China
- Publication Type:Journal Article
- Keywords:
circulating tumor cell;
non-small cell lung cancer;
chemokine receptor 9
- From:
Journal of Medical Postgraduates
2019;32(9):948-953
- CountryChina
- Language:Chinese
-
Abstract:
Objective Circulating tumor cells (CTCs) have potential value in the clinical application of various tumors. This study was to investigate the role of CTCs and their chemokine receptor CCR9 in the invasion and metastasis of non-small cell lung cancer (NSCLC). Methods From May 2018 to June 2019, a total of 62 patients with NSCLC in the clinical oncology center of The People's Hospital of Guangxi Zhuang Autonomous Region were enrolled in this study. The CanpatrolTM CTC technique was used to detected the expressions of CTCs and CCR9 in CTCs in peripheral blood of patients. Furthermore, the relationships between expression levels of CTCs, CCR9 and clinical, pathological characteristics of NSCLC patients were analyzed. Results CTCs were detected in 56 of 62 (90.3%) NSCLC patients. CTCs counts were associated with TNM stage, lymph node metastasis and distant metastasis of NSCLC (P<0.05). In the analysis of clinical correlation between CTC subtypes and NSCLC, epithelial CTCs counts were related to TNM stage and distant metastasis of NSCLC (r=0.296 and r=0.273, P<0.05). Additionally, counts of mixed type CTCs were also correlative with NSCLC tumor metastasis (r =0.253, P =0.047). Finally, we found that the positive rate of CCR9 in mixed type CTCs was associated with distant metastasis of NSCLC (r=0.353, P=0.038). Conclusion CTCs counts and subtypes were correlated with TNM stage and metastasis of NSCLC. The expression level of CCR9 on CTC was expected to be a biomarker to evaluate the risk of tumor metastasis in NSCLC.
