The role of intestinal microorganism in tumor treatment
10.16571/j.cnki.1008-8199.2019.08.017
- VernacularTitle: 肠道微生物在肿瘤治疗中的作用
- Author:
Yang OUYANG
1
;
Qi WU
1
;
Sheng-rong SUN
1
Author Information
1. Department of Breast and Thyroid Surgeryy, Renming Hospital of Wuhan University, Wuhan 430060, Hubei, China
- Publication Type:Journal Article
- Keywords:
intestinal microbiota;
tumor immunity;
chemotherapy;
immunotherapy
- From:
Journal of Medical Postgraduates
2019;32(8):872-876
- CountryChina
- Language:Chinese
-
Abstract:
The intestinal microbiota plays a crucial role in the innate and acquired immune responses. It regulates cancer initiation, progression, and response to therapies. This article focuses on the effect of intestinal microbiota on chemotherapy and immunotherapy. Intestinal microorganisms can activate the peripheral immune system, induce anti-tumor immune surveillance. Specific bacteria significantly affects anti-tumor immunity and the response to chemotherapy and immunotherapy. Proliferation, metastasis of specific bacteria or using of antibiotics induced intestinal microbiota disorders can change the efficacy of chemotherapy and immunotherapy. In the future, precision medicine can predict the patients’ response to drugs through the composition of intestinal microbes, regulate the initiation and development of tumors and the response to treatment by changing the composition of intestinal microbiome.
