Research of CircRNAs in the diagnosis and treatment of common orthopedic diseases
10.16571/j.cnki.1008-8199.2019.07.022
- VernacularTitle: CircRNAs在骨科常见病诊治中的研究进展
- Author:
Peng HE
1
;
Zhen-fang WU
1
;
Xiao-wei LIU
1
;
Bin XU
1
Author Information
1. Department of Orthopaedic, Jingling Hospital, Nanjing University School of Medicine/General Hospital of Eastern Theater Command, PLA, Nanjing 210002, Jiangsu, China
- Publication Type:Journal Article
- Keywords:
circular RNA;
non-coding RNA;
orthopaedic diseases
- From:
Journal of Medical Postgraduates
2019;32(7):780-784
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNA is a special kind of endogenous non-coding RNA which is widely existing in eukaryotic cells. More studies confirmed that most circRNAs were produced in the process of RNA shearing and played a vital role in the occurrence and development of many diseases. Though there was not much research on circRNAs related to orthopaedic diseases in recent years, study found that circRNAs played a great significant role in the pathogenesis, diagnosis, target therapy of degenerative diseases(osteoarthritis, lumbar degenerative disease), metabolic diseases(osteoporosis) and motor system tumor(osteosarcoma). This study summarizes the research progress of circRNAs in orthopaedic diseases.
