AKT/mTOR/STATs signaling pathway regulates various immune cells that mediate MS
10.16571/j.cnki.1008-8199.2019.07.020
- VernacularTitle: 免疫细胞内的AKT/mTOR/STATs信号通路与多发性硬化症的研究进展
- Author:
Zhi-kang ZHANG
1
;
Qin-jie WENG
1
Author Information
1. Zhejiang University College of Pharmaceutical Sciences, Hangzhou 310058,Zhejiang,China
- Publication Type:Journal Article
- Keywords:
multiple sclerosis;
AKT/mTOR/STATs;
helper T cells;
macrophages polarization;
treg;
B cells
- From:
Journal of Medical Postgraduates
2019;32(7):771-775
- CountryChina
- Language:Chinese
-
Abstract:
AKT/mTOR/STATs signaling pathway not only plays an important role in tumor growth, but also in the regulation of immune system. Activated AKT promotes the activation of downstream signaling pathways mTORC1 and mTORC2 through phosphorylation. mTOR is currently being considered as an important regulator of immune system and plays an important role in regulating the function and metabolism of various immune cells. Multiple sclerosis (MS) is an autoimmune deficiency disease whose pathogenesis has not been fully elucidated. This article focuses on the regulation of AKT/mTOR/STATs signaling pathways in various immune cells such as macrophage M1/M2 polarization, B cell proliferation and differentiation, helper T lymphocyte (Th cell) proliferation and differentiation, and Treg cell proliferation and differentiation, which would be helpful to illustrate the role of the AKT/mTOR/STATs signaling pathway in mediating the regulation of immune cells in MS.
