The role of intestinal microbiota in tumorigenesis and treatment
10.16571/j.cnki.1008-8199.2019.06.002
- VernacularTitle: 肠道微生物在肿瘤发生和治疗中的作用
- Author:
Chen-chen WANG
1
;
Yong-zhan NIE
1
Author Information
1. State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032, Shaanxi, China
- Publication Type:Journal Article
- Keywords:
intestinal microbiota;
cancer;
chemotherapy;
immunotherapy
- From:
Journal of Medical Postgraduates
2019;32(6):566-571
- CountryChina
- Language:Chinese
-
Abstract:
With the deepening of research on intestinal microbiota, more and more evidence indicates that intestinal microbiota affects various physiological processes of the human body and is closely related to tumors, Researches show that intestinal microbiota can promote tumorigenesis, enhance the antitumor effect of chemotherapeutic drugs, mediate chemoresistance, regulate the effect of immunotherapy, and reduce intestinal damage during radiotherapy. The phenomena and mechanisms revealed in the above studies are incredible. Based on the above correlation, the genus found in the study are expected to become the new target of tumor prevention and treatment. The evidence obtained from current animal and clinical trials is refreshing, however, in view of the complexity of human intestinal microecology and the limitations of human understanding, its potential role in tumorigenesis and treatment still needs systematic and in-depth research.
