The progress of immune escape-related molecule B7-H1 on malignant tumors with multidrug resistance

VernacularTitle: 免疫逃逸相关分子B7⁃H1影响恶性肿瘤多药耐药的研究进展
Author: Xu-mei CHEN ¹ ; Qing LUO ¹
Author Information

1. Department of Oncology, Affiliated Hospital of Zunyi Medical College,Zunyi 563000,Guizhou,China
Publication Type:Journal Article
Keywords: multidrug resistance of tumor; cancer immune escape; B7; B7-H1; epithelial-mesenchymal transition; P-glycoprotein
From: Journal of Medical Postgraduates 2019;32(5):536-539
CountryChina
Language:Chinese
Abstract: Malignant tumors with multidrug resistance is one of the major reasons for the failure of tumor treatment, and it is also an important issue in the field of cancer treatment. In recent years, with the continuous research on tumor immune microenvironment, the status of tumor immune escape is deeply understood. The close relationship between the abnormal expression of related molecules B7-H1 and tumor resistance is constantly recognized that multidrug resistant tumor may be more sensitive to immune system surveillance and killing than chemotherapy-sensitive tumor. The article reviews the progress of immune escape-related molecule B7-H1 in multidrug resistance of malignant tumors.