Advances of the mode of clinical pharmacy care in the era of precision medicine
10.16571/j.cnki.1008-8199.2019.05.002
- VernacularTitle: 精准医学时代下临床药学监护模式新进展
- Author:
Xiao-hui HUANG
1
;
Guo-hua ZHOU
1
Author Information
1. Department of Pharmacology, Jingling Hosptal, Nanjing University School of Medicine / General Hospital of Eastern Theater Command,PLA,Nanjing 210002,Jiangsu,China
- Publication Type:Journal Article
- Keywords:
precision medicine;
clinical pharmaceutical care;
personalized medication;
precision medication;
pharmacokinetics/pharmacodynamics;
PK/PD;
liquid biopsy
- From:
Journal of Medical Postgraduates
2019;32(5):455-461
- CountryChina
- Language:Chinese
-
Abstract:
Precision medicine has become a new mode of modern medicine, and personalized medication is the important embodiment of clinical application of precision medicine. The advances of life science technologies greatly facilitated precision medicine, and also promoted the shift of the mode of clinical pharmacy care from rational drug use and individualized medication to precision medication. To achieve"one person, one mode" clinical dosage regimens,it is necessary to rely on the supports of advanced life science technologies and precisely analyzing and accurately characterizing the biomarker clusters related to individual differences among patients, pathological differences of disease, and disease progression. This article illustrated the recent advances in the application of pharmacokinetics/pharmacodynamics, omics technology and liquid biopsy to the design of dosage regimen, prediction of therapeutic effect and adverse drug reactions, etc. in the era of precision medicine. Furthermore, the development direction of the new model of clinical pharmaceutical care faced on the precision medicine is prospected.
