Postoperative clinicopathological features of the patients with micropapillary lung adenocarcinoma
- VernacularTitle: 微乳头型肺腺癌患者术后临床病理学特征及影响因素分析
- Author:
Cui-cui ZHANG
1
;
Zhen HE
1
;
Shao-mei LI
1
;
Hong TANG
1
;
Li-li WANG
1
;
Yu-feng WU
1
;
Dong-dong ZHAO
1
;
Li YANG
1
;
Sen YANG
1
;
Cong XU
1
;
Ming-yue WANG
1
;
Wen FENG
1
;
Qi-ming WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: lung adenocarcinoma; micropapillary; postoperative; ALK fusion protein
- From: Journal of Medical Postgraduates 2019;32(3):248-252
- CountryChina
- Language:Chinese
- Abstract: Objective Studies are rarely reported on the factors influencing prognosis of surgically resected lung adenocarcinoma with a micropapillary pattern (LAC-MPP). This study aimed to explore the clinicopathological characteristics and risk factors of surgically resected LAC-MPP. Methods We retrospectively analyzed 384 cases of LAC treated in Henan Cancer Hospital between June 2015 and December 2017, which were classified into an MPP group (n = 82) and a non-MPP control group (n = 302) according to the results of postoperative pathology. We determined the expression of the fusion protein anaplastic lymphoma kinase (ALK), analyzed its association with the clinicopathological features of LAC-MPP, and explored the risk factors of postoperative MPP. Results Compared with the non-MPP group, the LAC-MPP patients showed a significantly higher expression of ALK (0.03% vs 12.20%, P < 0.05), rate of bronchial invasion (30.80% vs 48.78%, P < 0.05) and vascular tumor thrombus (0.99% vs 25.61%, P < 0.05), but a lower mutation rate of the epidermal growth factor receptor (EGFR) (64.24% vs 51.22%, P < 0.05). Multivariate logistic regression analysis revealed that the expression of ALK, vascular tumor thrombus, and age were significantly associated with the risk of postoperative MPP. Conclusion There is a high incidence rate of ALK expression in LAC-MPP patients after operation, which may provide some new ideas for the clinical treatment of the disease. Special attention should be paid to the expression of the ALK fusion protein and vascular tumor thrombus, and age in patients with LAC-MPP after operation.
