Relationship of preoperative blood lymphocyte-to-monocyte ratio with the clinicopathological features and prognosis of penile cancer
10.16571/j.cnki.1008-8199.2019.02.008
- VernacularTitle: 阴茎癌患者术前淋巴细胞与单核细胞比值与临床病理特征及预后的相关研究
- Author:
Meng⁃zhen WANG
1
;
Bin FU
1
Author Information
1. Department of Urology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China
- Publication Type:Journal Article
- Keywords:
penile cancer;
lymphocyte⁃to⁃monocyte ratio;
clinicopathological features;
prognostic value
- From:
Journal of Medical Postgraduates
2019;32(2):153-157
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aimed to investigate the relationship of the preoperative blood lymphocyte-to-monocyte ratio (LMR) with the clinicopathological features and prognosis of penile cancer. Methods We collected the clinicopathological data on 44 cases of penile cancer treated by surgery in our hospital between January 2000 and January 2018. Based on the preoperative LMR, we divided the patients into a low-LMR (LMR < 3.4, n=21) and a high-LMR group (LMR ≥ 3.4, n=23), compared the clinicopathological features between the two groups of patients, performed log-rank univariate analysis on the prognostic factors, and investigated the independent risk factors affecting the prognosis using the Kaplan-Meier survival curve and COX regression model. Results Log-rank univariate analysis revealed that the tumor diameter, cell grade and LMR were the risk factors affecting the recurrence-free survival (RFS) (P<0.05) and that postoperative lymph node metastasis, invasion of nerves and LMR were those affecting the overall survival (OS) of the penile cancer patients (P<0.05). The median RFS was significantly longer in the high-LMR than in the low-LMR group (26 vs 7 months, P=0.010), and so was the median OS (73 vs 29 months, P=0.045). COX multivariate survival analysis showed preoperative LMR to be the risk factor affecting RFS and OS of the patients (P < 0.05). The tumor recurrence rate was significantly lower (HR = 0.398, 95% CI: 0.174-0.909) and the OS rate markedly higher (HR = 0.428, 95% CI: 0.185-0.994) in the high-LMR than in the low-LMR group. Conclusion Penile cancer patients with a higher LMR have longer RFS and OS and are less susceptible to tumor invasion of the nerves. Preoperative LMR plays a valuable role in predicting the postoperative survival of penile cancer patients.
