Expression and clinical significance of serum ubiquitin in esophageal squamous cell carcinoma
10.16571/j.cnki.1008-8199.2019.12.009
- VernacularTitle: 血清泛素在食管鳞癌中的表达及临床意义
- Author:
Yi-ren XU
1
;
Peng-fei LIU
1
;
Hui-min JIA
2
;
Yi GAO
1
;
Fang-jun WANG
1
;
Wei-dong SHEN
1
;
Teng-fei LI
1
Author Information
1. Department of Gastroenterology, the Affiliated Jiangyin Hospital of Nantong University, Jiangyin 214400, Jiangsu,China
2. School of Radiation Medicine and Protection, Medical College of Soochow University, Soochow 215000, Jiangsu, China
- Publication Type:Journal Article
- Keywords:
ubiquitin;
esophageal squamous cell carcinoma;
serum squamous cell carcinoma antigen;
carcinoembryonic antigen
- From:
Journal of Medical Postgraduates
2019;32(12):1276-1279
- CountryChina
- Language:Chinese
-
Abstract:
Objective Ubiquitin-proteasome system (UPS) plays a central role in the development of esophageal cancer. However, As the executor of UPS, the expression and clinical significance of detection of serum ubiquitin (UB) in Esophageal Squamous Cell Carcinoma(ESCC) patients have not been fully elucidated. The aim of this study was to investigate the expression and diagnostic value of serum ubiquitin (UB) in ESCC. Methods A total of eighty-eight ESCC patients and forty healthy controls from February 2018 to May 2019 at the Affiliated Jiangyin Hospital of Nantong University were enrolled. Serum UB was measured by ELISA, and serum squamous cell carcinoma antigen (SCC) and carcinoembryonic antigen (CEA) were determined by chemiluminescence method. The ROC curve was used to analyze the diagnostic value of each indicator. Besides, the correlation between serum UB and clinicopathological features of ESCC were analyzed. Results The level of serum UB in ESCC group was significantly higher than that in the control group[(41.96±3.273)ng/ml vs (80.86±7.993)ng/ml, P<0.05]. The level of serum UB in ESCC patients was related to lymphatic metastasis and tumor stage (P<0.05). The sensitivity of UB, SCC, CEA and the three combined diagnosis of ESCC were 65.9%, 52.3%, 51.1%, and 76.1%, respectively. The AUC under the ROC curve were 0.690, 0.677, 0.635, and 0.795, respectively. Conclusion Serum UB is highly expressed in ESCC and is closely related to tumor progression. Combined with SCC and CEA, UB can improve the sensitivity of diagnosis of ESCC and can be used as an effective serological screening biomarker.
