Research progresses of inflammasome in the pathogenesis of acute pancreatitis
10.16571/j.cnki.1008-8199.2019.11.022
- VernacularTitle: 炎性小体在急性胰腺炎发病机制中的研究进展
- Author:
Ya-hui GONG
1
Author Information
1. Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Gunangxi, China
- Publication Type:Journal Article
- Keywords:
acute pancreatitis;
inflammasome;
NLRP3
- From:
Journal of Medical Postgraduates
2019;32(11):1228-1232
- CountryChina
- Language:Chinese
-
Abstract:
Acute pancreatitis (AP) is a common clinical emergency. Aseptic inflammation caused by the death of acinar cells is the early pathological change of AP. However, the main mechanism of aggravation of AP is the subsequently excessive inflammation which leads to multiple organ dysfunctions. Among them, the assembly and activation of inflammatory corpuscles are involved in the pathogenesis. It has shown that metabolic regulation of inflammatory corpuscle activation and its regulatory effectors play an important and decisive role in AP and its inflammatory response mechanism. This article reviews the structure and function of inflammasomes and their role in the pathogenesis of AP.
