The role of mitochondrial membrane permeability transition pore in apoptosis

VernacularTitle: 线粒体膜通透性转换孔在细胞凋亡中的作用
Author: Juan WU ¹ ; Bi-xi LI ¹
Author Information

1. Department of Anesthesiology , Central Theater Command General Hospital ,Wuhan 430070,Hubei,China
Publication Type:Journal Article
Keywords: mitochondria; apoptosis; mitochondrial permeability transition pore
From: Journal of Medical Postgraduates 2019;32(11):1222-1227
CountryChina
Language:Chinese
Abstract: Mitochondria play a central role in various apoptotic pathways within cells, changes of mitochondrial permeability transition(MPT) is the key point, which is mainly regulated by mitochondrial permeability transition pore(mPTP). So far, the structural model of mPTP, the way of mPTP participating in apoptosis and the regulatory nodes are still unclear. Our aim is to summarize mechanism of mitochondria mediate apoptosis, currently recognized structural model of mPTP, the pathological changes of all components of mPTP during apoptosis and the possible damage mechanisms underneath. mPTP is closely related to apoptosis, inhibit the opening of mPTP will reduce apoptosis. Therefore, interventions acting on inhibitomg mPTP opening can be helpful to prevent and treat diseases.