Advances in the roles of FOXD2-AS1 in carcinoma and its regulatory mechanisms
10.16571/j.cnki.1008-8199.2019.11.018
- VernacularTitle: FOXD2⁃AS1在肿瘤中的功能与调控机制的研究进展
- Author:
Zeng-tao HU
1
;
Cang-hai GUAN
1
;
Yu-qiao ZHAO
1
;
Xing-ming JIANG
1
Author Information
1. Department of Pancreatobiliary Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang, China
- Publication Type:Journal Article
- Keywords:
carcinoma;
long non-coding RNA;
FOXD2-AS1;
regulatory mechanisms
- From:
Journal of Medical Postgraduates
2019;32(11):1207-1211
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNA (lncRNA) is a group of non-coding RNA with length larger than 200 nucleotides. LncRNAs have limited or no protein-coding capacity due to lacking of open reading frame. Recent studies indicated that lncRNAs were involved in various cellular processes and their aberrant expression might lead to tumor development and progression. FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) was found to exhibit aberrant expression in various malignancies, and its dysregulation level was closely related with prognosis of cancer patients. The biological functions and molecular regulatory mechanisms of FOXD2-AS1 in tumors will be summarized in this paper.
