The role and research progress of PLOD2 in tumor metastasis

VernacularTitle: 赖氨酸羟化酶2在肿瘤转移中的研究进展
Author: Xiao-hong KANG ¹
Author Information

1. Department of Oncology, the First Affiliated Hospital of Xinxiang Medical University ,Weihui 453100, Henan,China
Publication Type:Journal Article
Keywords: procollagen-lysine，2-oxoglutarate 5-dioxygenase 2; tumor metastasis; tumor microenvironment; collagen fiber remodeling
From: Journal of Medical Postgraduates 2019;32(10):1099-1103
CountryChina
Language:Chinese
Abstract: Tumor invasion and metastasis are the main factors leading to poor prognosis of cancer patients.In recent years, studies have found that collagen fiber remodeling in extracellular matrix(ECM) can promote tumor invasion and metastasis . Lysine hydroxylase 2(PLOD2) is the only lysine hydroxylase that changes the pattern of collagen fiber cross-linking and remodeling. It is highly expressed in many tumors and is closely related to tumor invasion and metastasis,Therefore, in-depth study of the role and mechanism of PLOD2 in tumor metastasis is of great scientific value for judging tumor prognosis and preventing tumor invasion and metastasis.This article reviews the recent advances in the role and potential mechanisms of PLOD2 in tumor invasion and metastasis.