Correlation between thyroid hormone levels and nonalcoholic fatty liver disease in euthyroid middle-aged and older people
10.16571/j.cnki.1008-8199.2019.01.016
- VernacularTitle: 甲状腺功能正常中老年人甲状腺激素与非酒精性脂肪肝的相关性
- Author:
Yan-wei FENG
1
;
Dan-dan LIU
1
;
Kuo LI
1
;
Man LI
1
;
Hai-yan YANG
1
;
Wen-xia CUI
1
;
Lei GAO
1
;
Chun WANG
1
;
Yun HU
1
Author Information
1. Department of Geriatric, the Affiliated Drum Tower Hospital of Nanjing University, Nanjing 210008, Jiangsu, China
- Publication Type:Journal Article
- Keywords:
middle-aged and older people;
thyroid hormone;
non-alcoholic fatty liver disease
- From:
Journal of Medical Postgraduates
2019;32(1):73-77
- CountryChina
- Language:Chinese
-
Abstract:
Objective The prevalence of nonalcoholic fatty liver disease(NAFLD) is increasing in middle-aged and older people. This article aimed to analyze the relationship between thyroid hormone and NAFLD in euthyroid middle-aged and older people.Methods We retrospectively analyzed 589 euthyroid patients aged 40 years or older who were hospitalized in our department from January 2015 to December 2017. According to the Results of abdominal ultrasound, they were divided into NAFLD group (n=217) and non-NAFLD group (n=372). We compared the differences of general data between two groups and analyzed the association of thyroid hormones(FT3, TSH) with metabolic indexes and the risk of NAFLD.Results TSH and FT3 in NAFLD group were significantly higher than those in non-NAFLD group (respectively 2.18±1.01 mIU/L versus 1.74±0.77 mIU/L, P<0.001; 4.54±0.72 pmol/L vs 4.05±0.83 pmol/L, P<0.001). After adjusting for age and sex, TSH was positively correlated with BMI, abdominal circumference, and LDL (r, P respectively were 0.117, 0.005; 0.136, 0.001; 0.086, 0.037). FT3 was positively correlated with LDL (r=0.098, P=0.017), and negatively correlated with FPG and HbA1c (r, P respectively were -0.161, <0.001; -0.139, 0.001). With the increase of TSH and FT3 quartiles, the risk of NAFLD showed a significantly increasing trend (P<0.01). Logistic regression analysis showed that abdominal circumference, BMI, ALT, TG, TSH, and FT3 were independent risk factors of NAFLD. Conclusion TSH and FT3 are risk factors of NAFLD in euthyroid middle-aged and older people, which can be used as a good serological indicator of NAFLD.
