The target sites and structural characteristic of bispecific antibodies in cancer therapy
10.16571/j.cnki.1008-8199.2018.09.020
- VernacularTitle: 双特异性抗体在肿瘤治疗中的靶向位点及结构研究进展
- Author:
Xiao LI
1
;
Li-rong YANG
1
;
Lin LI
1
;
Zong-liu HOU
1
Author Information
1. Key Laboratory,Yanan Hosptal, Kunming Medical University/ Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province,Kunming 650051,Yunnan, China
- Publication Type:Journal Article
- Keywords:
bispecific antibodies;
tumor;
therapeutic target;
theoretical
- From:
Journal of Medical Postgraduates
2018;31(9):995-1000
- CountryChina
- Language:Chinese
-
Abstract:
Bispecific antibodies, that are the second generation of new type of antibodies with two specific antigens or epitopes binding sites, can combine with target cells and effector cells (or molecules) at the same time. The recent studies demonstrated that Bispecific antibodies possess the immense therapeutic potential for cancer, ASID and autoimmune diseases. In this review, the various targets and function, the underlying mechanisms, and the application progress of Bispecific antibodies in cancer therapy were discussed.
