Comparative study on genotype distribution of HPV infection in the tissues of cervical squamous cell carcinoma and cervical adenocarcinoma
10.16571/j.cnki.1008-8199.2018.08.012
- VernacularTitle: 宫颈鳞癌及腺癌组织HPV感染型别分布的对比研究
- Author:
Cai-ge SHI
1
;
Yun GU
2
;
Jian-xiang GENG
3
;
Xin GU
3
;
Xue-mei FAN
3
;
Xiao-lan XU
3
;
Yu WANG
3
;
Jing MEI
3
;
Xue ZHAO
3
Author Information
1. Department of Obstetrics and Gynecology, Zhuhai Health Hospital of Women and Children, Zhuhai 519000, Guangdong, China
2. Department of Pathology, Maternity Hospital of Nanjing Medical University, Nanjing 210004,Jiangsu, China
3. Department of Pathology, the Third Affiliated Hospital of Nanjing Traditional Chinese Medical University/ Specialized Committee of Human Papillomavirus Infection Diseases of Cross-Strait Association of Precision Medicine, Nanjing 210001,Jiangsu, China
- Publication Type:Journal Article
- Keywords:
human papillomavirus；cervix tissue；squamous cell carcinomas；adenocarcinoma；genotyping
- From:
Journal of Medical Postgraduates
2018;31(8):840-843
- CountryChina
- Language:Chinese
-
Abstract:
Objective There are few large sample data reports of comparative study on genotype distribution of human papillomavirus (HPV) infection in the tissues of cervical squamous cell carcinoma and cervical adenocarcinoma in China. This study aimed to investigate the clinical value of genotype distribution of HPV infection in the tissues of cervical squamous cell carcinoma and cervical adenocarcinoma in regional (mainly in Jiangsu Province) patients.Methods We collected 1044 paraffin tissue specimens of female cervical squamous cell carcinoma (826 cases) and cervical adenocarcinoma (218 cases) in 29 hospitals from November 1978 to December 2017. HPV DNA was extracted from the tissues and through the combination of gene-chip and polymerase chain reaction technology, 23 genotypes of HPV were detected in all the tissues of cervical squamous cell carcinoma and cervical adenocarcinoma, and comparative study was conducted on the genotype distribution of HPV infection.Results Among 1044 cases of cervical squamous cell carcinoma and cervical adenocarcinoma, 901 were found with HPV and the detection rate was 86.30%. The detection rate of cervical squamous cell carcinoma was 91.53% (756/826), among which 16，18，58，33，52，31 types were the most common and the detection rate of 16 type was significantly higher than that of 18 types (56.84% vs 9.93%, P<0.05). The detection rate of cervical adenocarcinoma was 66.51% (145/218), among which 16，18，31，33，52，58 types were the most common, and the detection rates of 16 type and 18 type was of no significant (35.29% vs 32.35%, P>0.05).Conclusion The HPV detection rates are different in the regional female cervical squamous cell carcinoma and cervical adenocarcinoma tissues. 16,18,31,33,52 and 58 types are the most common genotypes in cervical squamous cell carcinoma and cervical adenocarcinoma. The detection rate of 16 type is overly higher than that of 18 type in cervical squamous cell carcinoma, while the detection rates of 16 type and 18 type in cervical adenocarcinoma are very close.
