The application of serum endotoxin detection in the diagnosis of artificial prosthetic joint loosening
10.16571/j.cnki.1008-8199.2018.08.009
- VernacularTitle: 血清内毒素在判断人工关节假体松动中的应用
- Author:
Qing-gang CAO
1
;
Jia MENG
1
;
Ni-rong BAO
1
;
Chun-feng WANG
2
;
Jian-ning ZHAO
1
Author Information
1. Department of Orthopaedic Surgery, Jingling Hospital, Nanjing University School of Medicine / Nanjing General Hospital of Nanjing Military Region, PLA, Nanjing 210002, Jiangsu, China
2. Department of Orthopaedics,Guangji Hospital of Wuhu, Wuhu 241000, Anhui, China
- Publication Type:Journal Article
- Keywords:
serum endotoxin detection;
periprosthetic joint infection;
aseptic loosening;
infectious loosening
- From:
Journal of Medical Postgraduates
2018;31(8):828-830
- CountryChina
- Language:Chinese
-
Abstract:
Objective The dynamic detection of endotoxin is of great significance for the early diagnosis and treatment of prosthesis loosening after joint replacement. This study aimed to explore and analyze the clinical significance and efficacy of endotoxin detection in prosthetic joint loosening after joint replacement.Methods Fifty-eight patients who underwent arthroplasty in the department of orthopedics in Nanjing General Hospital from January 2015 to June 2016 were selected for prospective study. The patients were divided into the infection loosening group (patients with infectious loosening after arthroplasty, n=15), the aseptic loosening group (patients with aseptic loosening of after arthroplasty, n=23) and the control group (patients were normal after arthroplasty, n=20) according to the postoperative complications. Endotoxin was detected with MB-80 microbial dynamic rapid detection system. We compared the endotoxin level and the ROC curve was made to acquire the sensitivity and specificity under the different cut-off values. Eventually find the best diagnostic threshold.Results The levels of endotoxin in the infection loosening group and the aseptic loosening group \[(0.56±0.11, 0.49±0.08) ng/mL\] were significantly higher than that in the control group \[(0.24±0.06) ng/mL\]. The difference was statistically significant (P<0.01). The difference was not statistically significant between the infection loosening group and the sterile loosening group (P>0.05). ROC curve analysis showed that when the serum endotoxin concentration was 0.36 ng/mL, the Youden index was the highest, which could be the best cut-off value for diagnosis. It had the best accuracy to judge the prosthesis loosening with a sensitivity of 66.7% and specificity of 88.2%.Conclusion The endotoxin can be a good indicator for early diagnosis of prosthesis looseness. It is helpful to the diagnosis of the prosthesis loosening after arthroplasty.
