An overview oflncRNA involved in articular cartilage injury and repair
10.16571/j.cnki.1008-8199.2018.12.021
- VernacularTitle: LncRNA在软骨损伤与修复中作用机制的研究进展
- Author:
Pin ZHANG
1
;
Lei ZHANG
1
;
Jian-ning ZHAO
1
Author Information
1. Department of Orthopedics, Jinling Hospital, Nanjing Medical University/Nanjing General Hospital of Nanjing Military Region, PLA, Nanjing 210002, Jiangsu, China
- Publication Type:Journal Article
- Keywords:
lncRNA;
miRNA;
chondrogenesis;
chondrocytes;
osteoarthritis
- From:
Journal of Medical Postgraduates
2018;31(12):1325-1328
- CountryChina
- Language:Chinese
-
Abstract:
Long noncoding RNAs (lncRNAs) are important regulators for a variety of biological process. miRNAs appear to be important modulators of chondrogenesis and osteoarthritis (OA). LncRNAs are widely involved in the regulation of proliferation and apoptosis of chondrocytes as sponge of microRNAs. In this review, we discuss the role of lncRNA in cartilage repairation from the aspects of cartilage injury, chondrocyte proliferation and chondrocyte apoptosis. These findings will promote the development of novel molecular drugs which regulate the balance of cartilage injury and repairation.
