Pooled analysis of prognostic significance of CX3CL1 mRNA expression level in patients with non-small cell lung cancer
10.16571/j.cnki.1008-8199.2018.12.015
- VernacularTitle: CX3CL1 mRNA表达水平对肺腺癌及鳞状细胞癌患者的预后价值分析
- Author:
Jian LIU
1
;
Qing LI
1
;
Wan-da PENG
1
;
Song HU
1
;
Chun-lai FENG
1
;
Chong LI
1
Author Information
1. Department of Respiration, the Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu, China
- Publication Type:Journal Article
- Keywords:
lung adenocarcinoma；lung squamous cell carcinoma；CX3CL1；prognosis
- From:
Journal of Medical Postgraduates
2018;31(12):1296-1300
- CountryChina
- Language:Chinese
-
Abstract:
Objective The prognostic expression level and prognostic significance of CX3CL1 in patients with non-small cell lung cancer(NSCLC) need further investigation. The purpose of this paper was to investigate the effects of various CX3CL1 mRNA expression levels on patients with NSCLC.Methods By retrieving lung-cancer related gene expression profile data in NCBI GEO database and TCGA of UCSC Cancer Browser, 8 datasets were included based on inclusion and exclusion criteria. All the datasets were collated and standardized through R statistical software. Univariate and multivariate Cox models were conducted for prognosis analysis of CX3CL1 in each dataset. HR values of all the datasets were pooled by meta algorithm.Results High-expression of CX3CL1 mRNA in tumor tissues of lung adenocarcinoma was a positive prognostic factor for overall survival(pooled HR=0.53; 95% CI=0.43-0.65 in univariate analysis; pooled HR=0.52; 95% CI=0.42-0.64 in multivariate analysis). However, in lung squamous cell carcinoma, there was no significant association between CX3CL1 expression and overall survival (pooled HR=1.09; 95% CI=0.82-1.45 in univariate analysis; pooled HR=1.18; 95% CI=0.88-1.58 in multivariate analysis).Conclusion The mRNA level of CX3CL1 in lung adenocarcinoma was positively correlated with better prognosis, but there was no correlation between CX3CL1 mRNA level and prognosis in patients with lung squamous cell carcinoma. CX3CL1 may be used as a potential prognostic marker for patients with lung adenocarcinoma.
