Simultaneously detect three illegal additive components in Yinhuang soft capsule by TLC-SERS
10.3969/j.issn.1006-0111.201908092
- VernacularTitle:TLC-SERS同时检测银黄软胶囊中3种非法添加成分
- Author:
Weiguo SONG
1
;
Yonghui LU
1
;
Zhonghu ZHANG
2
;
Huimin ZHANG
1
Author Information
1. Shandong Academy of Chinese Medicine, Jinan 250014, China.
2. Shandong Institute for Food and Drug Control, Jinan 250101, China.
- Keywords:
Yinhuang soft capsule;
illegal addition;
TLC-SERS
- From:
Journal of Pharmaceutical Practice
2020;38(2):166-169
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a simultaneous detection of diclofenac sodium, fenbufen and rotundine hydrochloride illegally added in Yinhuang soft capsules by TLC-SERS. Methods The samples to be measured were placed on the silica gel plate, and the thin layer was developed with petroleum ether-ethyl acetate (3:5). Location detection was carried out under 254 nm ultraviolet lamp. Nano-silver colloidal solution was sprayed at each spot of separation according to the optimum conditions, and then qualitative identification was done by TLC-SERS. Results A method for simultaneous determination of diclofenac sodium, fenbufen and rotundine hydrochloride illegally added in Yinhuang soft capsule by TLC-SERS was established. And the minimum detection limits of three chemical constituents were determined. Conclusion TLC-SERS was a rapid, accurate and sensitive method for the simultaneous and rapid detection of diclofenac sodium, fenbufen and rotundine hydrochloride illegally added into Yinhuang soft capsule.
