Determination of the content of Gd3+ in gadoteric acid meglumine salt injection by ICP-MS method
10.3969/j.issn.1006-0111.201908132
- VernacularTitle:用电感耦合等离子体质谱法测定钆特酸葡胺注射液中游离Gd3+的含量
- Author:
Qirong WANG
1
;
Jieyi CHEN
1
;
Miao SUN
1
;
Yuping CHEN
1
;
Feng YANG
1
Author Information
1. Department of Inorganic Chemistry, School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Keywords:
ICP-MS;
gadoteric acid meglumine salt injection;
Gd3+;
content determination
- From:
Journal of Pharmaceutical Practice
2020;38(2):124-128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a method for determining the content of Gd3+ in gadoteric acid meglumine salt injection. Methods ICP-MS was used. The separation column was a metal chelate column (1-ml Chelating Sepharose column), column temperature was normal temperature. Flow rate was 1 ml/min. Injection volume was 500 μl. Atoms were measured by ICP-MS with a molecular weight of 157 (The molecular weight of Gd was 157). The carrier gas was argon. Results The linear range of Gd3+ mass concentration was 0-500 ng/ml (r=1.000); The precision, stability and repeatability of the sample recovery test were all in accordance with the requirements. Conclusion The method was simple in operation, accurate in results and good in repeatability, which could be used to determine the content of Gd3+ in gadoteric acid meglumine salt injection.
