Lung Involvement Is an Early Clue to Severe Dengue
- VernacularTitle:肺部受累是重症登革热的早期线索
- Author:
Yun-feng SHI
1
;
Xiao-han SHI
1
;
Lai-zhi ZHOU
1
;
Jun-hui BA
1
;
Wei-qiang GAN
2
;
Yu-wei Tong
3
,
4
;
Ben-quan WU
1
Author Information
1. Department of MICU；Department of Pulmonary and Critical Care Medicine，The Third Affiliated Hospital of Sun Yat- sen University，Guangzhou 510630，China
2. Department of Infectious Diseases，The Third Affiliated Hospital of Sun Yat-sen University，Guangzhou 510630，China
3. Department of Cardiology，Guangzhou Eighth People&rsquo
4. s Hospital， Guangzhou 510060，China
- Publication Type:Journal Article
- Keywords:
dengue, lung involvement, severe dengue, multi-organ dysfunction syndrome
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2019;40(5):774-780
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To investigate the differences of lung involvement between dengue and severe dengue.【Methods】227 dengue patients admitted in The Third Affiliated Hospital of Sun Yat-sen University from July 2014 to October 2018 were enrolled. The clinical characteristics，treatment and outcome of the patients were analyzed to explore the differences of lung involvement between dengue and severe dengue （SD）. 【Results】 The rate of old age ，smoking ，hypertension，diabetes and cerebrovascular disease was higher in dengue with lung involvement group（DWLI）than dengue without lung involvement group（DWOLI）（χ2 were 25.146，3.847，10.326，7.177，and 5.355，P was 0.050 for smoking，the others were < 0.05）. The rate of cough and breathlessness was higher in DWLI（χ2 were 11.465 and 6.068，P were 0.001 and 0.014），as well as in SD subgroup（χ2 were 4.585 and 6.717，P were 0.032 and 0.010）. C-reactive protein and procalcitonin were increased in DWLI（Z were - 2.591 and - 3.033，P were 0.010 and 0.002）. The rate of pleural effusion was higher in SD subgroup（χ2 = 4.987，P = 0.026）. Bilateral lung infiltration was correlated with SD（χ2 = 5.910，P =0.015）. The rate of acute liver injury，acute kidney injury and multi-organ dysfunction syndrome（MODS）was higher in DWLI（χ2 were 7.044，7.059，and 11.315，P were 0.008，0.008 and 0.001）. The rate of anti-virus，anti-bacteria and combined therapy was higher in DWLI（χ2 were 13.156，32.845，and 12.684，P all were < 0.001）.【Conclusion】Dengue patients who were with old age，smoking，or suffered from underlying disease of hypertension，diabetes and cerebrovascular disease were vulnerable to lung involvement. Cough，breathlessness，pleural effusion and bilateral lung infiltration were signs of severe dengue. Attention should be paid to dengue with lung involvement.
