Inflammatory Infiltration Characteristics of Nasal Inverted Papillomas
- VernacularTitle:鼻内翻性乳头状瘤局部炎症浸润特征分析
- Author:
Chen CAO
1
;
Si-fei YU
2
;
Xue-xue GUO
1
;
Yu-tao ZHOU
1
;
Chun-wei LI
1
;
He-xin CHEN
1
Author Information
1. Department of Otolaryngology，the First Affiliated Hospital of Sun Yat-sen University，Guangzhou 510080，China
2. Institute of Immunology，Zhongshan School of Medicine，Sun Yat-sen University，Guangzhou 510080，China
- Publication Type:Journal Article
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2019;40(3):445-452
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To investigate the histopathological patterns and local inflammatory infiltration characteristics in patients with nasal inverted papilloma.【Methods】Tissues of 50 patients with nasal inverted papilloma and 20 controls which all underwent surgery in the Department of Otolaryngology，the First Affiliated Hospital of Sun Yat-sen University between June ，2016 and June ，2018. The histological patterns and inflammatory cell infiltration were evaluated and analyzed for association with clinical characteristics by immunohistochemistry and flow cytometry.【Results】Eosinophils， neutrophils，macrophages were significantly elevated in nasal inverted papilloma compared with control samples（P < 0.001）. CD4+ T cells（P = 0.005），TH1 cells（CD4+ IFN-γ+ T cells，P = 0.005）were also elevated in inverted papilloma，except CD8 + T cells（P = 0.990）and TC1 cells（CD8 + IFN- γ + T cells，P = 0.538）compared with controls. Flow cytometry shows the predominating T lymphocytes in nasal inverted papilloma were CD4+ T cells，but they were CD8+ T cells in the controlsamples. IFN- γ protein level was significantly increased in papilloma tissues compared with control samples analyzed by Luminex ，P < 0.001. IFN- γ protein level was also significantly increased in non-recurrence compared with recurrence analyzed by Luminex，P < 0.001. The remaining clinical pathological features were not significantly correlated with the degree of local inflammatory cells infiltration in NIP.【Conclusion】Inflammation may have potential roles in nasal inverted papilloma.
