Analysis of differences in clinical characteristics between multifocal and multicentric breast cancer and unifocal breast cancer
- VernacularTitle:多灶和多中心性乳腺癌与单灶乳腺癌的临床特征差异分析
- Author:
Han-chen ZHANG
1
;
Zhuo-chen LIN
2
;
Hong-li WANG
3
;
Hai-qing LIU
1
;
Zi-liang CHENG
1
;
Zhuo WU
1
Author Information
1. Department of Radiology，SUN Yat-sen Memorial Hospital，SUN Yat-sen University，Guangzhou 510120，China
2. Department of Medical Statistic and Epidemiology，School of Public Health，SUN Yat-sen University，Guangzhou 510080，China
3. Breast Tumor Center，SUN Yat-sen Memorial Hospital，SUN Yat-sen University，Guangzhou 510120，China
- Publication Type:Journal Article
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2019;40(3):423-430
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the differences of clinical medicine ，magnetic resonance imaging（MRI）and pathology in multifocal and multicentric breast cancer（MMBC）and unifocal breast cancer（UBC）. 【Methods】 In this retrospective analysis，55 MMBC and 68 UBC patients with pathology confirmed from April 2016 to February 2018 were enrolled，and the characteristics and difference of routine pathological types，molecular subtypes and MR enhancement types were compared. The relationships between MMBC ，UBC and the methods of clinical treatment were studied by correspondence analysis（CA）.【Results】Significant difference was observed between routine pathological types of MMBC and UBC（P < 0.001）. The high grade invasive ductal carcinoma was more frequent in maximal lesions of MMBC than in UBC lesions，whereas there was no statistical correlation between molecular subtypes，molecular subtypes and MR enhancement types（P = 0.265，P = 0.152）. However，there was statistical difference in masses enhancement（P = 0.013）. CA showed that the molecular subtypes of MMBC and UBC were the key factors for clinical treatment. In addition ，HER- 2（+）and Luminal B type breast cancer showed high correlation with treatment method，while triple-negative showed low correlation with treatment method.【Conclusions】The pathology types of the maximal lesions of MMBC were less aggressive than UBC lesions. There was significant correlation between clinical treatment and molecular subtypes of MMBC and UBC. Therefore，individualized treatments are recommended on the basis of biological characteristics in both MMBC and UBC.
