ExpressionandClinicalSignificanceofJunDinMolecularSubtypesof InvasiveBreastCarcinoma
- VernacularTitle:JunD在浸润性乳腺癌分子亚型中的表达及意义
- Author:
Xin-zhen DAI
1
;
Xian-jun MI
1
;
Shou-jun ZHONG
1
;
Li-feng DUAN
1
;
Wei-hong YANG
1
;
Xiang-yu LIU
1
;
Xiu-mei XU
1
;
Zhao-hua HUANG
1
Author Information
1. DepartmentofPathology，ZhongshanBoaiHospital，Zhongshan，Guangdong528403，China
- Publication Type:Journal Article
- Keywords:
invasivebreastcarcinoma；molecularsubtypes；immunohistochemical；JunD
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2019;40(6):946-952
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】ToinvestigatetheexpressionandclinicalsignificanceofJunDinmolecularsubtypesofinva⁃ sivebreastcarcinoma，benignandmalignantbreastlesions.【Methods】Immunohistochemicalexaminationwasperformed for160patientswithinvasivebreastcarcinoma，191patientswithbreastintraductalproliferativelesionsand20patients withnormalbreasttissue.【Results】①ComparisonwithothersubtypesshowedthattheexpressionofJunDwassignificantly increasedinTBNCsubtype（P＜0.05）anddifferencesbetweenothersubtypeswerenotstatisticallysignificant（P＞0.05） . ②TheexpressionofJunDininvasivebreastcarcinomawaslowerthanthatinbreastintraductalproliferativelesionsand normalbreasttissuse（P <0.01） .③Basedonimmunohistochemicalstaining，highpositiveexpressionrateofJunDwas associatedwithlowhistologicalgrade（P <0.01）.ThereisnocorrelationbetweenJunDandtumordiameter，age，lymph nodes，ER，PRandhistologicalgrade（P >0.05） .【Conclusions】TheexpressionofJunDwassignificantlyincreasedin TBNCsubtype.TostudytheexpressionofJunDinTBNCsubtypeofinvasivebreastcarcinomamayprovideanevaluation intargetedtreatment.ThedifferentexpressionofJunDinbenignandmalignantbreastlesionsmaybehelpfulfortheir differentialdiagnosis.
