HBsAg Levels Normalized to the Same Hepatic Parenchyma Cell Volume Is Correlated with Pathological Progression but Not HBeAg Status
- VernacularTitle:经相同肝实质细胞体积分摊的血清HBsAg水平与肝组织 病理进展相关而与HBeAg状态无关
- Author:
Lei TAN
1
;
Tao WU
1
;
Yan LV
1
;
Wei-li WANG
1
;
Jie REN
1
;
Rong-qin ZHENG
1
;
Ze-qian WU
2
Author Information
1. Department of Ultrasound，The Third Affiliated Hospital of Sun Yat-sen University，Guangzhou 510630，China
2. Department of Infectious Diseases，The Third Affiliated Hospital of Sun Yat-sen University，Guangzhou 510630，China
- Publication Type:Journal Article
- Keywords:
serum HBsAg levels；hepatic parenchyma cell volume（hepatic cell quantities）；liver inflammation grades；hepatic fibrosis stages
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2019;40(5):747-753
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To study retrospectively the serum hepatitis B surface antigen（HBsAg）and HBsAg normal⁃
ized to the same hepatic parenchyma cell volume（HPCV），namely，the same hepatic cell quantities，between HBeAg-
positive and HBeAg-negative chronic hepatitis B（CHB）.【Methods】A total of 168 CHB patients who had undergone liv⁃
er biopsy and test of serum HBsAg levels due to their disease in the Third Affiliated Hospital of SunYat-sen University
were selected as the study subjects. The serum HBsAg levels，as well as HBsAg levels normalized to HPCV（hepatic cell
quantities）were compared between HBeAg-positive and HBeAg-negative CHB，respectively.【Results】There was statis⁃
tically significant difference in serum HBsAg levels between HBeAg-positive and HBeAg-negative CHB（P = 0.028），
while there was no statistical difference in HBsAg normalized to HPCV（P = 0.073）. There were no correlations between
serum HBsAg and liver inflammation grades（HBeAg-positive：r s = 0.020，P = 0.876 & HBeAg-negative：r s = 0.037，P =0.711）. Similarly，there were no correlations between HBsAg and hepatic fibrosis stages（HBeAg-positive：r s = 0.087，
P = 0.488 & HBeAg-negative：r s = 0.144，P = 0.148）. Nevertheless，statistically significant positive correlations were
shown between HBsAg normalized to HPCV and liver inflammation grades（HBeAg-positive：r s = 0.309，P = 0.012 &
HBeAg-negative：r s = 0.389，P < 0.001）. Similarly，the HBsAg normalized to HPCV and hepatic fibrosis stages were
shown to be statistically significantly correlated（HBeAg-positive：r s = 0.490，P < 0.001 & HBeAg-negative：r s = 0.599，
P < 0.001）.【Conclusions】Serum HBsAg normalized to HPCV but not HBsAg levels，is correlated with liver inflamma⁃
tion grades as well as hepatic fibrosis stages positively in both HBeAg-positive and HBeAg-negative CHB. But there is
no difference in serum HBsAg levels normalized to HPCV between HBeAg-positive and HBeAg-negative CHB.
