Correlation Analysis between Serum Complement C3，C4 Levels and LDL-C in Patients with Premature Coronary Artery Disease
- VernacularTitle:早发冠心病患者血清补体C3、C4水平与LDL-C的相关性分析
- Author:
Rui-ting LIN
1
,
2
;
Shi-yun CAI
1
,
2
;
Zhi-qiong PAN
1
,
2
;
Hao-ran CHEN
1
,
2
;
Cong CHEN
1
,
2
;
Hai-feng ZHANG
3
Author Information
1. 1.Department of Cardiovascular，Maoming People&prime
2. s Hospital，Maoming 525000，China；
3. 2.Department of Cardiology， Sun Yat-sen Memorial Hospital//Guangdong Provicial Key Laboratory of Arrhythmia and Electrophysiology ，Sun Yat-sen University Guangzhou 510120，China
- Publication Type:Journal Article
- Keywords:
premature coronary artery disease, complement C3, complement C4, LDL-C
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2019;40(4):554-559
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】The aim of this study was to investigate the associations between serum complement C3，C4 and low density lipoprotein cholesterol（LDL- C）levels and early- onset coronary heart disease.【Methods】We enrolled 255 cases of coronary angiography confirmed coronary artery disease from January 2018 to September 2018. All the patients were divided into early- onset coronary heart disease group（108 cases）and late- onset coronary heart disease group（147 cases）. Besides ，100 healthy subjects were enrolled and used as controls. Serum levels of C3 ，C4 and LDL-C were analyzed by automatic biochemical analyzer.【Results】Levels of serum C3，C4 and LDL-C in early-onset coronary heart disease group，late-onset coronary heart disease group and healthy control group were significantly different（P < 0.05）. In early-onset coronary heart disease group，C3 and C4 were positively correlated with LDL-C（P < 0.05）. However ，there was no significant correlation （P > 0.05） between C3 ，C4 and LDL- C in late- onset coronary heart disease group and healthy control group.【Conclusions】The levels of C3 and C4 were positively correlated with LDL-C only in the early-onset coronary heart disease patients.
