Predictive Value of Blood Eosinophil in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps in Guangdong Adults
- VernacularTitle:广东地区成人外周血嗜酸性粒细胞检测对嗜酸性粒细胞性鼻息肉的诊断意义
- Author:
Wei-feng KONG
1
;
Rui ZHENG
1
;
Hao YAO
2
;
Wei-hao WANG
1
;
Mei-jiao LI
1
;
Hui-yi DENG
1
;
Xue-kun HUANG
1
;
Qin-tai YANG
1
Author Information
1. 1. Department of Otorhinolaryngology，Head and Neck Surgery，The Third Affiliated Hospital，Sun Yat-sen University， Guangzhou 510630，China；
2. 2. Department of Bone Oncology，The First Affiliated Hospital，Sun Yat-sen University， Guangzhou 510080，China
- Publication Type:Journal Article
- Keywords:
eosinophil, chronic rhinosinusitis, nasal polyps, basophil, predictor, Guangdong Province
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2019;40(4):546-553
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To investigate the predictive value of blood eosinophil in eosinophilic chronic rhinosinusitis with nasal polyps（eosCRSwNP）by analyzing the characteristics of eosCRSwNP adult patients in Guangdong Province， China.【Method】From Oct.2017 to Sep.2018，a total of 108 eosCRSwNP adult inpatients scheduled for surgery in Department of Otorhinolaryngology，Head and Neck Surgery，The Third Affiliated Hospital，Sun Yat-sen University were enrolled. They were divided into eosCRSwNP（n = 39） and non-eosCRSwNP（n = 69） group by the pathologic features. The demographic and clinical features were collected and compared.【Results】The eosCRSwNP group accounted for 36.1% while non-eosCRSwNP group accounted for 63.9% in our study. A higher prevalence of allergic rhinitis，asthma and higher blood IgE level，bilateral Lund-Mackay score of posterior ethmoid sinus，ethmoid to maxillary Lund-Mackay score ratio， peripheral blood eosinophil absolute count and percentage and peripheral blood basophil absolute count and percentage were found in eosCRSwNP patients. Only peripheral blood eosinophil absolute count and percentage were independent predictors of eosCRSwNP. The cutoff absolute value of 0.275×109/L demonstrated a sensitivity of 74.4% and a specificity of 72.5% while the cutoff relative value of 4.32% demonstrated a sensitivity of 74.4% and a specificity of 73.9%.【Conclusion】Non-eosCRSwNP was predominant in Guangdong. EosCRSwNP differs from non-eosCRSwNP in many clinical features，while peripheral blood eosinophil count and percentage were independent predictors of eosCRSwNP.
