DestructionandProtectionStrategyofBlood-brainBarrierDuringIschemicStroke
- VernacularTitle:血脑屏障在缺血性卒中病程中的破坏与保护策略
- Author:
Zheng-qi LU
1
Author Information
1. DepartmentofNeurology，TheThirdAffiliatedHospital，SunYat-senUniversity，Guangzhou510630，China
- Publication Type:Journal Article
- Keywords:
blood-brainbarrier；ischemicstroke；inflammation
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2019;40(5):641-647
- CountryChina
- Language:Chinese
-
Abstract:
Blood-brainbarrier（BBB），abarrierstructurebasedonbrainmicrovascularendothelialcells，playsan importantroleinmaintainingthehomeostaticmicroenvironmentofcentralnervoussystem（CNS）.Underthepathological conditionsofischemicstroke，localinflammationandchangesinthestatusandstructureofcellsleadtoBBBdisruption. AsaresultofBBBpermeabilityrising，variousbloodcomponents，especiallyactivatedinflammatorycellsorinflammatory factors，passthroughthedamagedBBBtoreachcerebralinfarctionareaandaggravatebraininjury.Thisarticlereviews themechanismofBBBdisruptionbythefunctionofactivatedcellsclusteredininfarctionareaafterischemicstrokeand brieflysummarizesourteam′scurrentworkonrepairingBBBinjuries.
