Research Progress of Developmental Neurotoxicity Induced by General Anesthetics
- VernacularTitle:全麻药对发育期大脑神经毒性的研究进展
- Author:
Xing-rong SONG
1
,
2
Author Information
1. Department of Anesthesiology，Guangzhou Women and Children&prime
2. s Medical Center，Guangzhou Medical University，Guangzhou，510623，China
- Publication Type:Journal Article
- Keywords:
non-obstetric surgery, infants, developing brain, general anesthetics；neurotoxicity
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2019;40(4):493-502
- CountryChina
- Language:Chinese
-
Abstract:
With the rapid development of surgery and the expansion of indications for surgical treatment ，the number of non-obstetric operations during pregnancy and infant operations has been increasing. Most of these operations need to be performed under general anesthesia，and the developing brain of fetus and infants are inevitably exposed to general anesthetics. Therefore，in recent years，the neurotoxicity effects of general anesthetics on the developing brain have become the focus and controversy in the medical sciences. Especially in 2016，US Food and Drug Administration（FDA）added black box for warning of general anesthetics commonly used in clinic，which caused confusion among doctors，patients and staffs in the related fields. Therefore，we will elaborate the preclinical and clinical studies of neurotoxicity of general anesthetics in combination with the characteristics of developing brain.
