Prognostic Predictors of Adrenocortical Carcinoma in Adults
- VernacularTitle:成人肾上腺皮质癌预后的影响因素分析
- Author:
Shao-hua LI
1
;
Ju-ying TANG
1
;
Shao-ling ZHANG
1
;
Li-li YOU
1
;
Ke-xu XIANG
1
;
Diao-zhu LIN
1
;
Ying GUO
1
;
Li YAN
1
;
Jian HUANG
2
Author Information
1. Department of Endocrinology，Sun Yat-sen Memorial Hospital，Sun Yat-sen University，Guangzhou 510120，China
2. Department of Urology，Sun Yat-sen Memorial Hospital，Sun Yat-sen University，Guangzhou 510120，China
- Publication Type:Journal Article
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2019;40(1):62-69
- CountryChina
- Language:Chinese
-
Abstract:
adrenocorticalcarcinoma；cortisolhypersecretion；hypokalemia；prognosis:【Objective】To analyze the prognostic determinants of adreno cortical carcinoma（ACC）inadults.【Methods】Alladult patients who were admitted to SunYat-sen Memorial Hospital，SunYat-sen University from December 2011 to March 2017 and pathologically diagnosed ACC were included in this study.Thec linical data and preoperative laboratory examinations of those patients were analyzed retrospectively. Overall survival or disease-free survival was calculated and survivalcurves were plotted by Kaplan-Meier and compared by log-rank test. Harzardratios（HRs） with their 95% confidenceintervals（CIs） were calculated by univariate and multivariate Coxregression model.【Results】The study included 20 adult patients with ACC， with a median follow-up of 13months （6~73 months）. The mean survival time of those patients was 49.2 months（6~73months），with a 1-year survival rate of 70.0%. The results of multivariate Coxregression analysis revealed that the presense of cortisol hypersecretion（HR=23.60，95%CI：2.49-223.79，P=0.006） and hypokalemia（HR=23.60，95%CI：2.49-223.79，P=0.006）were predictors of poorprognosis of ACC. Moreover，in 18 patients with completely resected ACC，the presense of hypokalemia resulted in a worse disease-free survival.【Conclusion】The presense of cortisol hypersecretion and hypokalemiaare independent risk factors associated with poorprognosis of ACC in adults.
