Relation among Ultrasound Findings，Clinical Significance and Expression of FosB in Invasive Breast Cancer
- VernacularTitle:浸润性乳腺癌中FosB的表达与超声征象及临床病理的相关性
- Author:
Xin-zhen DAI
1
;
Xian-jun MI
1
;
Shou-jun ZHONG
1
;
Li-feng DUAN
1
;
Wei-hong YANG
1
;
Xiang-yu LIU
1
;
Xiu-mei XU
1
;
Zhao-hua HUANG
1
Author Information
1. Department of Pathology，Zhongshan Boai Hospital，Zhongshan 528403，China
- Publication Type:Journal Article
- Keywords:
FosB, invasive breast cancer, ultrasound, immunohistochemical
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2020;41(1):135-142
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To investigate the expression of FosB in invasive breast cancer and its correlation to the ultrasound findings and clinical significance.【Methods】Immunohistochemical and ultrasound examination were performed for 155 cases with invasive breast cancer，36 cases with paracancerous tissue and 30 cases with normal breast tissue. To investigate the correlations between the different expression of FosB with histological grade ，lymph nodes，and ultrasound findings.【Results】①The expression of FosB in paracancerous tissue and normal breast tissue was higher than that in invasive breast cancer（P＜0.01）. ②Based on immunohistochemical staining，high positive expression rate of FosB was associated with low histological grade，ER positive and PR positive（P＜0.05）. There was no correlation between FosB and age，tumor diameter，lymph nodes，Her2 and clinical stages（P＞0.05）③The expression of FosB was higher in microcalcification positive and lymph nodes bigger tissues（P＜0.05）. There was no correlation between FosB and tumor size， regular shape，boundary，posterior attenuation ratio and blood flow（P＞0.05）.【Conclusion】The expression of FosB in invasive breast cancer was lower than that in paracancerous tissue and normal breast tissue. The different expression of FosB was correlated with histological grade，ER positive and PR positive. To study the expression of FosB in invasive breast cancer may be helpful for differential diagnosis and targeted treatment. The different expression of FosB was correlated with microcalcification，lymph nodes，and combined FosB with ultrasound findings may contribute to prognostic evaluation of breast cancer.
