Relationship between Exhaled Nitric Oxide Concentration and Pulmonary Function/Airway Hyperresponsiveness in Asthmatic Children.
- Author:
Bong Seok CHOI
1
;
Hye Mi JEE
;
Yeo Hoon PARK
;
Kyung Won KIM
;
Myung Hyun SOHN
;
Kyu Earn KIM
Author Information
1. Department of Pediatrics and Institute of Allergy, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea. kwkim@yuhs.ac
- Publication Type:Original Article
- Keywords:
Nitric oxide;
Asthma;
Children;
Spirometry;
Bronchial hyperactivity;
Impulse oscillometry
- MeSH:
Asthma;
Child;
Humans;
Inflammation;
Methacholine Chloride;
Nitric Oxide;
Oscillometry;
Respiratory Function Tests;
Spirometry
- From:Pediatric Allergy and Respiratory Disease
2009;19(3):291-299
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Exhaled nitric oxide (eNO) has been proposed as a non-invasive marker for airway inflammation in asthma. Pulmonary function tests have been widely used in the diagnosis and management of asthma. Airway hyperresponsiveness (AHR) is one of the major features in asthma and usually assessed by the methacholine challenge test. The purpose of the present study was to assess the possible relationship between eNO and pulmonary function/AHR in asthmatic children. METHODS: There were 121 asthmatic children and 81 controls in the study. The eNO level was measured, the methacholline challenge test, spirometry, impulse oscillometry (IOS) and assessment of their bronchodilator responses were performed on all subjects. RESULTS: The asthma group had a higher eNO value than the control group [28.3 (15-55.75) vs. 20 (12.35-39.7) ppb, P=0.015]. The eNO level correlated positively with dFEV1 (r=0.230, P= 0.001). It correlate inversely with dR5 (r=-0.149, P=0.036), eNO with PC20 (r=-0.318, P<0.001) and with FEF25-75 (r=-0.17, P=0.015), but not with FEV1. CONCLUSION: This study suggests that eNO values may reflect AHR, as well as airway inflammation, but not pulmonary function.
