Analysis of clinical effects of elderly donor liver from organ donation after citizen's death in liver transplantation: a single-center experience
10.3969/j.issn.1674-7445.2020.02.014
- VernacularTitle:公民逝世后器官捐献高龄供肝肝移植的临床疗效分析：单中心经验
- Author:
Yunliang XIE
1
;
Zhou YANG
;
Qing YANG
;
Xiao FENG
;
Hui TANG
;
Wei LIU
;
Binsheng FU
;
Shuhong YI
;
Yang YANG
;
Guihua CHEN
Author Information
1. Department of Hepatic Surgery, Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
- Publication Type:Research Article
- Keywords:
Elderly donor liver;
Marginal donor liver;
Liver transplantation;
Organ donation;
Alanine aminotransferase;
Total bilirubin;
Primary nonfunction;
Initial poor graft function
- From:
Organ Transplantation
2020;11(2):271-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of marginal liver from elderly donors in liver transplantation. Methods According to the inclusion and exclusion criteria, the clinical data of 127 donors and recipients were retrospectively analyzed. According to the age of donors, 127 donors were divided into the elderly group (n=27) and control group (n=100). The recovery of liver function, the occurrence of postoperative complications and survival rate of the recipients after transplantation were statistically analyzed between two groups. Results The incidence of primary nonfunction (PNF) and initial poor graft function (IPGF) did not significantly differ between the elderly and control groups (both P > 0.05). Within postoperative 2 weeks, the average levels of alanine aminotransferase (ALT) and serum total bilirubin (TB) of liver transplant recipients in the elderly group was not significantly different from those in the control group (both P > 0.05). There was no significant difference in the incidence of postoperative complications in the postoperative elderly group compared with the control group (all P > 0.05). The 1-and 3-year survival rates of the recipients in the elderly group were 84% and 78% respectively, which did not significantly differ from 89% and 79% in the control group (both P > 0.05). Conclusions Strict and sufficient quality evaluation and functional maintenance should be done for elderly donor livers. It can achieve good transplantation results by intraoperative fine operation, reducing bleeding and trauma, shortening the time of cold ischemia and operation, strengthening postoperative monitoring and implementing enhanced recovery after surgery.
