Research progress on biomarkers of rejection risk in organ transplantation
10.3969/j.issn.1674-7445.2020.02.003
- VernacularTitle:器官移植排斥反应风险生物标志物研究进展
- Author:
Bingyi SHI
1
;
Wen CHEN
;
Zhijia LIU
Author Information
1. Organ Transplantation Institute of the 8th Medical Center of Chinese PLA General Hospital, Beijing 100091, China
- Publication Type:Research Article
- Keywords:
Organ transplantation;
Transplantation immunity;
Rejection;
Transplantation pathology;
Immune cell;
Non-human leukocyte antigen antibody;
Exosomes;
Cell-free DNA(cfDNA);
Combination gene prediction
- From:
Organ Transplantation
2020;11(2):194-
- CountryChina
- Language:Chinese
-
Abstract:
Rejection is the main cause of transplantation failure. Currently, the specificity and sensitivity of clinical parameters are relatively poor, which cannot accurately prompt the exact cause of rejection. It is of great clinical significance to explore novel biomarkers for monitoring the rejection. In this article, the latest research progress on the biomarkers of rejection risk in organ transplantation were summarized from the perspectives of transplantation pathology, immune cells and regulatory immune cells, non-human leukocyte antigen antibodies, exosomes, cell-free DNA and combination gene prediction, aiming to provide reference for early warning and treatment of rejection in organ transplantation.
