Effects of Dengzhan Shengmai Capsule Combined with Isosorbide Mononitrate on Serum MMP- 9，TIMP-1，Blood Lipid Level and Cardiac Function in Patients with Unstable Angina Pectoris
- VernacularTitle:灯盏生脉胶囊联合单硝酸异山梨酯对不稳定型心绞痛患者血清MMP-9、TIMP-1、血脂水平及心功能的影响
- Author:
Lin TANG
1
;
Zongbao LI
2
;
Ruina BAI
3
Author Information
1. Dept. of TCM，Hainan Provincial People’s Hospital，Haikou 570311，China
2. Emergency Center，Hainan Provincial People’s Hospital，Haikou 570311，China
3. Dept. of Cardiovascular Medicine，Xiyuan Hospital，Chinese Academy of Traditional Chinese Medicine，Beijing 100091，China
- Publication Type:Journal Article
- Keywords:
Dengzhan shengmai capsules;
Isosorbide mononitrate;
Unstable angina pectoris;
TIMP-1;
MMP-9;
Blood lipid;
Cardiac function
- From:
China Pharmacy
2019;30(20):2851-2854
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To study the effects of Dengzhan shengmai capsules combined with isosorbide mononitrate on serum TIMP-1 and MMP-9 levels， blood lipid level and cardiac function in patients with unstable angina pectoris （UAP）. METHODS： Totally 198 UAP patients admitted to our hospital from Apr. 2016 to Apr. 2019 were selected， and divided into observation group （n＝102） and control group （n＝96） according to therapy plan. Control group received Isosorbide mononitrate tablets 40 mg， qd， orally； observation group additionally received Dengzhan shengmai capsules， 2 capsules per time， tid， orally， on the basis of control group. Both groups received treatment for consecutive 4 weeks. The clinical efficacy， serum levels of MMP-9 and TIMP-1， blood lipid indexes [low density lipoprotein cholesterol （LDL-C）， high density lipoprotein cholesterol （HDL-C）， triglyceride （TG）， total cholesterol （TC）]， cardiac function indexes [end-diastolic volume （EDV）， left ventricular ejection fraction （LVEF）， end-systolic volume （ESV）] and ADR were compared between 2 groups. RESULTS： The total response rate of observation group was significantly higher than control group （91.18％ vs. 70.83％， P＜0.05）. Before treatment， there was no statistical significance in the levels of ESV， MMP-9， TIMP-1， TC， LDL-C， TG， HDL-C， EDV and LVEF between 2 groups （P＞0.05）. After treatment， the levels of MMP-9， TC， LDL-C， TG， ESV and EDV in 2 groups were decreased significantly in both groups， and the observation group was significantly lower than the control group （P＜0.05）； meanwhile， the levels of TIMP-1， HDL-C and LVEF in 2 groups were increased significantly， and the observation group was significantly higher than control group （P＜0.05）. There was no statistical significance in the incidence of total ADR in 2 groups （P＞0.05）. CONCLUSIONS： Dengzhan shengmai capsules combined with isosorbide mononitrate show good clinical efficacy for UAP， which can effectively reduce serum MMP-9 level and increase serum TIMP-1 level， reduce blood lipid levels， as well as improve cardiac function for UAP patients， with good safety.
